The Greene Murder Case is a 1929 talking film produced and released by Paramount Pictures and based on the novel The Greene Murder Case, by S.S. Van Dine (Willard Huntington Wright). The novel had been published a year before this film was made. It stars William Powell in his second Philo Vance outing. Florence Eldridge and Jean Arthur costar.

The Greene Murder Case
Directed by	Frank Tuttle
Written by	Louise Long (screenplay) Richard H. Digges Jr. (intertitles,silent version)
Based on	The Greene Murder Case 1928 novel by S.S. Dine
Produced by	B. P. Schulberg
Starring	William Powell Florence Eldridge Jean Arthur
Cinematography	Henry Gerrard
Edited by	Verna Willis
Music by	Karl Hajos
Distributed by	Paramount Pictures
Release date	August 11, 1929
Running time	69 minutes
Country	United States
Language	English

In 1937, the film was remade as Night of Mystery.