All of Route 246 is a two-lane undivided highway. It starts at Route 148 as McPherson Street in Hopkins and heads eastward. The road soon leaves Hopkins and enters widespread farmlands. Less than a mile later, Route 246 meets the northern terminus of Route AC, a supplemental route. The route continues eastward for several miles, until it intersects Route E. There, it becomes concurrent with Route E, and moves south for two miles. After the route leaves Route E, it continues east towards Sheridan. The road passes through more farmland with a few trees, and crosses into Worth County. Near Sheridan, Route 246 shifts slightly north, and continues east toward the center of the village. Route 246 intersects the southern terminus of Route H, and leaves Sheridan. The road crosses over the One Hundred and Two River and shifts back southward. The route ends at Route 46 at a T-intersection a few miles east of Sheridan.^[1][2] The highest traffic count is east of Sheridan, where 541 vehicles travel the road daily, on average. The lowest traffic count is along the four miles (6.4 km) west of Route E, where 152 vehicles travel the road daily, on average.^[3]

Between 1918 and 1926, Route 46 was extended to Sheridan.^[4][5] Soon after, in 1933, it extended south, two miles east of Sheridan. The extension caused the road to Sheridan to become a spur route of Route 46.^[6][7] The spur route was then extended west into Nodaway County around 1948–1949, and was numbered supplemental route D.^[8][9] Four years later, the route was extended to Route 27 (now Route 148).^[9][10] In 1954, Route 246 was designated, starting from Sheridan, and ending at Route 46.^[10][11] The next year, Route 246 was extended to replace supplemental route D as the main connector from Hopkins to Route 46.^[11][12] The whole route was surfaced in concrete by 1959.^[13][14]