An underage Venkata Raya succeeded his father, the Emperor Achyuta Deva Raya as the Emperor of Vijayanagara and his maternal uncle Salakaraju Chinna Tirumala (Salakaraju Chinna Timmalayyadéva or Salakaraja Chinna Tirumalayyadeva) became the imperial regent. The latter, Salakaraju assassinated all the claimants to the throne including Venkata Raya and assumed full imperial powers. Only Sadasiva Raya (son of Ranga Raya), who had hidden himself in the fort of Gutti, escaped.

As soon as Salakaraju heard about the plans of Aliya Rama Raya and his brothers (Tirumala Deva Raya and Venkatadri Raya) to dethrone him, he invited the Turko-Persian Sultan of Bijapur Ibrahim Adil Shah I and placed him on the imperial throne of Vijayanagara for seven days. This was too much for the nobility of the empire to tolerate.

But they acted cleverly, offered full support to Salakaraju and requested him to send away Ibrahim Adil Shah I which he did after paying him a suitable compensation.

In 1543, Aliya Rama Raya and his supporters marched into Vijayanagara, killed Salakaraju and placed Sadasiva Raya on the throne.

• Prof K.A. Nilakanta Sastry, History of South India, From Prehistoric times to fall of Vijayanagar, 1955, OUP, New Delhi (Reprinted 2002)