Charles Leroy Pruiett (April 10, 1883 – March 6, 1953) was a pitcher in Major League Baseball who played from 1907 through 1908 for the Boston Americans and Red Sox. Listed at 5 ft 8 in (1.73 m), 176 pounds (80 kg), Pruiett batted left-handed and threw right-handed. He was born in Osgood, Indiana.

In a two-season career, Pruiett posted a 4–18 record with 54 strikeouts and a 2.83 ERA in 48 appearances, including 23 starts, seven complete games, three shutouts, five saves, and 232+1⁄3 innings of work.

Pruiett died in Ventura, California at age 69.