Samuel Jones Nicholls (May 7, 1885 – November 23, 1937) was a United States representative from South Carolina. He was born in Spartanburg, South Carolina. He attended Bingham Military Institute in Asheville, North Carolina; Wofford College, in Spartanburg, South Carolina; Virginia Polytechnic Institute in Blacksburg, Virginia; and the University of Chicago Law School. He was admitted to the bar in 1906 and commenced practice in Spartanburg.

Samuel Jones Nicholls
Member of the U.S. House of Representatives from South Carolina's 4th district
In office September 14, 1915 – March 3, 1921
Preceded by	Joseph T. Johnson
Succeeded by	John J. McSwain
Member of the South Carolina House of Representatives from Spartanburg County
In office January 8, 1907 – February 12, 1909
Personal details
Born	(1885-05-07)May 7, 1885 Spartanburg, South Carolina
Died	November 23, 1937(1937-11-23) (aged 52) Spartanburg, South Carolina
Resting place	Spartanburg, South Carolina
Political party	Democratic
Alma mater	Wofford College Virginia Polytechnic Institute University of Chicago Law School
Military service
Branch/service	South Carolina National Guard
Rank	Captain
Commands	Company I, First Infantry Regiment

Nicholls was the city attorney of Spartanburg and prosecuting attorney of Spartanburg County, South Carolina. He was a member of the South Carolina House of Representatives 1907-1908. He served by special appointment as circuit judge and as associate justice of the Supreme Court of South Carolina. He also organized and was captain for three years of Company I, First Regiment, South Carolina National Guard Infantry.

Nicholls was elected as a Democrat to the Sixty-fourth Congress to fill the vacancy caused by the resignation of Joseph T. Johnson. He was reelected to the Sixty-fifth and Sixty-sixth Congresses and served from September 14, 1915 to March 3, 1921 and declined to be a candidate for renomination in 1920. He resumed the practice of law in Spartanburg, South Carolina until his death there on November 23, 1937. He is buried in West Oakwood Cemetery.