Salyut 5 was launched at 18:04:00 UTC on 22 June 1976. The launch took place from Site 81/23 the Baikonur Cosmodrome in the Kazakh Soviet Socialist Republic, and used a three-stage Proton-K 8K82K carrier rocket with the serial number 290–02.^[1]

Upon reaching orbit, Salyut 5 was assigned the International Designator 1976-057A, whilst the North American Aerospace Defense Command gave it the Satellite Catalog Number 08911.^[2]

Salyut 5 was an Almaz spacecraft, the last of three to be launched as space stations after Salyut 2 and Salyut 3. Like its predecessors, it was 14.55 metres (47.7 ft) long, with a maximum diameter of 4.15 metres (13.6 ft). It had a habitable interior volume of 100 cubic metres (3,500 cu ft), and a mass at launch of 19,000 kilograms (42,000 lb). The station was equipped with a single docking port for Soyuz spacecraft, with the Soyuz 7K-T being the configuration in service at the time. Two solar arrays mounted laterally at the same end of the station as the docking port provided it with power. The station was equipped with a KSI capsule to return research data and materials.

Salyut 5 carried Agat, a camera which the crews used to observe the Earth. The German Kristall furnace was used for crystal growth experiments aboard the station^{[citation needed]}.

Four crewed missions to Salyut 5 were originally planned. The first, Soyuz 21, was launched from Baikonur on 6 July 1976, and docked at 13:40 UTC the next day.^[3] The primary objective of the Soyuz 21 mission aboard Salyut 5 was to conduct military experiments, however scientific research was also conducted, which included studying aquarium fish in microgravity and observing the Sun. The crew also conducted a televised conference with school pupils. Cosmonauts Boris Volynov and Vitali Zholobov remained aboard Salyut 5 until 24 August, when they returned to Earth landing 200 km southwest of Kokchetav. The mission had been expected to last longer, however the atmosphere within Salyut 5 became contaminated with nitric acid fumes from a fuel leak, which affected the crew's psychological and physical condition, necessitating an emergency landing.

On 14 October 1976, Soyuz 23 was launched carrying Vyacheslav Zudov and Valery Rozhdestvensky to the space station. During approach for docking the next day, a faulty sensor incorrectly detected an unexpected lateral motion. The spacecraft's Igla automated docking system fired the spacecraft's maneuvering thrusters in an attempt to stop the non-existent motion. Although the crew was able to deactivate the Igla system, the spacecraft had expended too much fuel to reattempt the docking under manual control. Soyuz 23 returned to Earth on 16 October without completing its mission objectives.

The last mission to Salyut 5, Soyuz 24, was launched on 7 February 1977. Its crew consisted of cosmonauts Viktor Gorbatko and Yury Glazkov, who conducted repairs aboard the station and vented the air which had been reported to be contaminated. Scientific experiments were conducted, including observation of the sun. The Soyuz 24 crew departed on 25 February. The short mission was apparently related to Salyut 5 starting to run low on propellant for its main engines and attitude control system.^[4]

The fourth planned mission, which would have been designated Soyuz 25 if launched, was intended to visit the station for two weeks in July 1977.^[5] It would have been crewed by cosmonauts Anatoly Berezovoy and Mikhail Lisun; the backup crew for the Soyuz 24 mission. The mission was cancelled for the above-mentioned shortage of propellant.^[6] The spacecraft which was constructed for the Soyuz 25 mission was reused for the Soyuz 30 mission to Salyut 6. Since it could not be refuelled, and no longer had the fuel to sustain crewed operations, the KSI recoverable capsule was ejected and returned to Earth on 26 February. Salyut 5 was deorbited on 8 August 1977 and burned up as it reentered the Earth's atmosphere.^[7]

• Space station for statistics of occupied space stations
• Salyut
• TKS spacecraft
• Almaz
• Mir
• Skylab
• International Space Station