Robert or Bob Humphreys may refer to:

• Robert Humphreys (politician) (1893–1977), U.S. senator from Kentucky
• Robert Humphreys (priest),19th-century Anglican priest in Ireland
• Robert Cunningham Humphreys (1905–1965), American Republican party operative
• Robert J. Humphreys (born 1950), judge of the Virginia Court of Appeals
• Robin Humphreys (Robert Arthur Humphreys, 1907–1999), British historian
• Laud Humphreys (Robert Allan Humphreys, 1930–1988), American sociologist and author
• Bob Humphreys (baseball) (born 1935), American baseball player
• Bob Humphreys (athlete) (born 1936), American track and field athlete
• Bob Humphreys (American football) (born 1940), American football placekicker
• Bob Humphreys (speedway rider) (born 1946), Australian speedway rider