Mixe may refer to:

• Mixe people, an ethnic group of Oaxaca, Mexica
• Mixe languages, the group of languages spoken by them
• Sierra Mixe, a district in Oaxaca, Mexico
• Roman Catholic Territorial Prelature of Mixes, in Oaxaca, Mexico
• Lit-et-Mixe, a commune in Nouvelle-Aquitaine
• Mix Country [fr], a historic region of the French Basque Country, which includes the present-day communes of Aïcirits-Camou-Suhast and Uhart-Mixe