Madame may refer to:

• Madam, civility title or form of address for women, derived from the French madame
• Madam (prostitution), a term for a woman who is engaged in the business of procuring prostitutes, usually the manager of a brothel
• Madame (1961 film), a Spanish-Italian-French film
• Madame (2017 film), a French comedy-drama film
• Madame (singer) (born 2002), Italian singer and rapper
• Madame, a puppet made famous by entertainer Wayland Flowers
• Madame (clothing), an Indian clothing company