Luis Manuel de los Santos Martinez (born December 29, 1966) is a Dominican former Major League Baseball first baseman. De los Santos played in the majors for parts of three seasons, including stints with the Kansas City Royals (1988-1989) and the Detroit Tigers (1991). Afterwards, de los Santos played professionally in several countries, including Mexico, Taiwan, Japan, and South Korea.

Following his major league career, de Los Santos played two seasons for Charros de Jalisco of the Mexican League, in 1991 and 1992. After spending a year in Triple-A Edmonton that did not see him get called up to the majors, de los Santos played in three seasons with the Brother Elephants between 1994 and 1996, which saw him lead the Chinese Professional Baseball League in RBI in 1995.

De los Santos played for the Yomiuri Giants of Nippon Professional Baseball in 1997.

Following his stint in Japan and a two-season hiatus from baseball, de los Santos played a year for Saraperos de Saltillo and a year for the KBO's Kia Tigers before playing 50 games for the then Baltimore Orioles' Triple-A affiliate, the Rochester Red Wings, in 2002.

Afterward, de los Santos would sign with Gary Southshore Railcats of the independent Northern League, and in 2003, played for Nettuno Baseball Club in the Italian Baseball League.