Dipoto was born to Gerard & Barbara Dipoto and has two siblings, Marc Dipoto and Lori Dipoto-Dorsey. He played high school baseball at Toms River High School North in Toms River, New Jersey. He enrolled at Virginia Commonwealth University (VCU) and played college baseball for the VCU Rams.^[2]

The Cleveland Indians selected Dipoto in the third round of the 1989 Major League Baseball Draft.^[3] He made his major league debut in 1993.

After the 1994 season, the Indians traded Dipoto with Paul Byrd, Dave Mlicki and a player to be named later (minor leaguer Jesus Azuaje) to the New York Mets for Jeromy Burnitz and Joe Roa.^[4]

After the 1996 season, he was traded by the Mets to the Colorado Rockies for Armando Reynoso.^[5]

Forced to retire during the spring of 2001, Dipoto went to work in the Colorado Rockies' front office as a special assistant to general manager Dan O'Dowd. In 2003, he became a scout for the Boston Red Sox, and in 2004 was a part of the World Series winning team as a scout. In 2005, he returned to the Rockies as the head of professional scouting. When Josh Byrnes, whom Dipoto had known since his days as a Rockies player, became the general manager of the Arizona Diamondbacks, Dipoto went with Byrnes to Arizona and became the director of scouting and player personnel.

Byrnes was fired on July 1, 2010, and Dipoto was named interim general manager.^[6] On September 22, Kevin Towers was named the new Diamondbacks' general manager. Dipoto was offered the opportunity to remain with the Diamondbacks.^[7]

On October 28, 2011, the Los Angeles Angels of Anaheim announced Dipoto would be their next general manager, replacing Tony Reagins.^[8] Angels' owner Arte Moreno said that "one of the reasons we hired Jerry is that I really liked the way he viewed baseball analytics." However, Dipoto and manager Mike Scioscia disagreed over the use of analytics in baseball decisions,^[9] and a rift developed between the two when Dipoto fired Mickey Hatcher from the role of the team's hitting coach.^[10] Despite rumors that the Angels might replace either Dipoto or Scioscia after the 2013 season,^[11] Moreno announced that both would return to the Angels for the 2014 season.^[12]

Tension between Dipoto and Scioscia continued during the 2015 season over the way Scioscia and his coaches delivered statistical reports developed by Dipoto and the front office to their players.^[13] Dipoto resigned from his position on July 1, 2015.^[14]

On August 12, 2015, the Boston Red Sox hired Dipoto in an advisory role.^[15] When the Seattle Mariners fired Jack Zduriencik after seven years with the club, they launched a GM search which lasted exactly one month, culminating with the hiring of Dipoto on September 28, 2015.^[1]

On September 1, 2021, the Mariners promoted Dipoto to president of baseball operations and signed him to a multi-year contract extension.^[16]

Dipoto and his wife, Tamie, have three children: Taylor, Jordan, and Jonah. He is a thyroid cancer survivor, having undergone curative thyroid surgery in 1994.^[17]

• Career statistics and player information from Baseball Reference, or Baseball Reference (Minors), or Retrosheet