The hospital has 262^[2] hospital beds and serves over 230 000 residents in Etobicoke and the surrounding areas. Annually, the hospital has over 50,270 outpatients, 15,785 inpatients, and has 70,000 emergency visits.^[3] It employs 1026 health care professionals, and has more than 200 affiliated family physicians and specialists.^[2] It also has 400 dedicated volunteers including a wide variety of co-operative education students. It is a member of the William Osler Health System group of hospitals.

The original hospital building was opened in 1972,^[3] following governmental investment and a major donations push led by a group of local volunteers.^[4] Although rearrangement and renovation followed over the decades since the hospital's opening, further expansion would occur more than 40 years later.

In 2018, Osler opened the Etobicoke Wellness Centre (EWC).^[5] The Wellness Centre represents a partnership between the hospital and various external partners, such as independent physicians and private businesses. It houses a number of Etobicoke General outpatient services, such as a fracture clinic, a pre-anesthesia care unit, diagnostic imaging, a diabetes education centre, and a 15-machine hemodialysis unit, newly opened in April 2020.^[5] The remainder of the building is dedicated to private clinics and businesses, such as LifeLabs.^[5]

Immediately following the opening of the Etobicoke Wellness Centre, a new patient tower (nicknamed the "west wing") was opened in June 2019.^[5] The patient tower houses a new emergency department, ICU, birthing unit, neonatal ICU, and a number of outpatient clinics.^[5]