The Bay of San Miguel (Spanish: Golfo de San Miguel) is a bay of the Gulf of Panama, located on the Pacific coast of Darién Province in eastern Panama.

The bay is located at 8°19′10″N 78°18′31″W / 8.3194444°N 78.3086111°W / 8.3194444; -78.3086111.

It is fed by the Tuira River. At its southern end is Cape Garachiné (also known as Point Garachina), and at its northern end is Punta San Lorenzo (a.k.a. Cape Gardo).