Incumbent Democratic Congressman William Lacy Clay Jr. faced no difficulty in seeking another term in this liberal, St. Louis–based district over Republican Mark Byrne and Libertarian Robb Cunningham.

Though confronted with a powerful Democratic wave, incumbent Republican Congressman Todd Akin easily won a third term over Democrat George Weber and Libertarian Tamara Millay.

Freshman incumbent Congressman Russ Carnahan, a Democrat, had an easy time in winning a second term in this fairly liberal district based in the southern portion of St. Louis.

Incumbent Democratic Congressman Ike Skelton, seeking his sixteenth term in this conservative, west-central Missouri–based district, overwhelmed Republican candidate Jim Noland, Libertarian nominee Bryce Holthouse, and Progressive Party candidate Mel Ivey and was victorious.

Coming from a surprisingly-close election in 2004, freshman incumbent Congressman Emanuel Cleaver, a Democrat, easily defeated Republican nominee Jacob Turk to win a third term in this fairly liberal district based in Kansas City.

In this conservative, northwest Missouri district, incumbent Republican Congressman Sam Graves easily dispatched with Democratic nominee Sara Jo Shettles, Libertarian candidate Erik Buck, and Progressive candidate Shirley Yurkonis to win a fourth term in Congress.

Incumbent Republican Congressman Roy Blunt, the House Majority Whip, found no difficulty in winning a sixth term in his very conservative district located in southwest Missouri.

In the most conservative district found in Missouri, incumbent Republican Congresswoman Jo Ann Emerson coasted to re-election, swamping Democratic nominee Veronica Hambacker and Libertarian nominee Branden McCullough.

This district, based in "Little Dixie," located in northeast Missouri, has a strongly conservative bent and incumbent Republican Congressman Kenny Hulshof sought and won a sixth term against several opponents.