1E or 1-E may refer to:

• 1st meridian east, a longitude coordinate
• ISS 1E
• Astra 1E, a communications satellite owned and operated by SES, and launched in 1995
• California Proposition 1E (2009), a defeated California ballot proposition
• 1E, UIC classification of the 2-10-0 train arrangement
• 1E, a designator of celestial objects discovered via Einstein Observatory
• 1E, inc - Software Company specializing in Digital Employee Experience (DEX) Gartner